Thiodiketopiperazines Produced by the Endophytic Fungus Epicoccum nigrum

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• 作者：Jia-Ming Wang ; Guang-Zhi Ding ; Lei Fang ; Jun-Gui Dai ; Shi-Shan Yu ; Ying-Hong Wang ; Xiao-Guang Chen ; Shuang-Gang Ma ; Jing Qu ; Song Xu ; Dan Du
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：July 23, 2010
• 年：2010
• 卷：73
• 期：7
• 页码：1240-1249
• 全文大小：374K
• 年卷期：v.73,no.7(July 23, 2010)
• ISSN：1520-6025

文摘

Thirteen new thiodiketopiperazines, epicoccin I (1), ent-epicoccin G (2), and epicoccins J−T (3−13), together with six known diketopiperazines (14−19), have been isolated from the endophytic fungus Epicoccum nigrum. The structures of 1, 2, and 10 were confirmed by X-ray crystallography, and the absolute configurations of 2, 4, 6, and 8 were assigned using Moshers’ method. Compounds 2, 6, 12, and 17 showed potent activities in vitro against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with IC₅₀ values of 3.07, 4.16, 4.95, and 1.98 μM, respectively. None of the 19 compounds exhibited detectable cytotoxic activities toward six tumor cell lines (A549, Be-l7402, BGC-823, HCT-8, HCT-116, and A2780) in the MTT assay.