Nickel-Catalyzed Regio- and Stereoselective Hydrocarboxylation of Alkynes with Formic Acid through Catalytic CO Recycling

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• 作者：Ming-Chen Fu ; Rui Shang ; Wan-Min Cheng ; Yao Fu
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：6
• 期：4
• 页码：2501-2505
• 全文大小：459K
• ISSN：2155-5435

文摘

By the combination of a Ni(II) salt, a bisphosphine ligand, and a catalytic amount of carboxylic acid anhydride, atom-economic hydrocarboxylation of various alkynes with formic acid can be achieved with high selectivity and remarkable functional group compatibility, affording α,β-unsaturated carboxylic acids regio- and stereoselectively. Both terminal and internal alkynes are amenable substrates. A mechanism proceeding through carbon monoxide recycling in a catalytic amount is demonstrated to be crucial for the success of this transformation.