Super paramagnetic Norbornene Copolymer Functionalized with Biotin and Doxorubicin: A Potential Unique Site-Specific Theranostic Agent

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• 作者：Saikat Mukherjee ; Diptendu Patra ; Himadri Dinda ; Ipsita Chakraborty ; Litesh Shashank ; Rangeet Bhattacharyya ; Jayasri Das Sarma ; Raja Shunmugam
• 刊名：Macromolecules
• 出版年：2016
• 出版时间：April 12, 2016
• 年：2016
• 卷：49
• 期：7
• 页码：2411-2418
• 全文大小：617K
• 年卷期：0
• ISSN：1520-5835

文摘

Polymer-based nanosystems have been extensively explored either as therapeutic agents or bioimaging probes in the cancer diagnosis. However, very few systems are successful in combining both therapy and imaging. Herein, a new class of norbornene based copolymer, Nor-Dox-Cob-Btn is proposed as potential theranostics agent for tumor diagonosis. The copolymer (Nor-Dox-Cob-Btn) with doxorubicin, cobalt carbonyl complex, and biotin as pendent functionalized group is synthesized, using ring opening metathesis polymerization (ROMP). The cell viability, drug release, NMR relaxation, NMR 1-D image and Epi fluorescence microscopy studies on Nor-Dox-Cob-Btn nanocarrier are thoroughly studied. The effect of nanocarrier on transverse relaxation (T₂) of water molecule and NMR 1-D image suggest that the nanocarrier has the potential application in magnetic resonance imaging agent. The T₂-weighted MRI agent, along with biotin receptor assisted pH responsive doxorubicin release from Nor-Dox-Cob-Btn, prompts us to envision this newly developed polymer for future application in theranostics.