Anti-inflammatory Endiandric Acid Analogues from the Roots of Beilschmiedia tsangii

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• 作者：Yun-Ting Huang ; Hsun-Shuo Chang ; Guei-Jane Wang ; Ming-Jen Cheng ; Chu-Huang Chen ; Yi-Jen Yang ; Ih-Sheng Chen
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：September 23, 2011
• 年：2011
• 卷：74
• 期：9
• 页码：1875-1880
• 全文大小：762K
• 年卷期：v.74,no.9(September 23, 2011)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1鈥?b>8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC₅₀ values of 9.59 and 16.40 渭M, respectively.