Highly Enantioselective Nitro-Mannich Reaction Catalyzed by Cinchona Alkaloids and N-Benzotriazole Derived Ammonium Salts
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- 作者：Yu Wei ; Wei He ; Yulong Liu ; Peng Liu ; Shengyong Zhang
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：February 3, 2012
- 年：2012
- 卷：14
- 期：3
- 页码：704-707
- 全文大小：305K
- 年卷期：v.14,no.3(February 3, 2012)
- ISSN：1523-7052
文摘
The catalytic enantio- and diastereoselective nitro-Mannich reaction of 伪-amido sulfones in the mixed solvent of toluene/H2O has been realized using a phase-transfer catalyst (PTC) derived from cinchona alkaloids and N-benzotriazole. It performed well over a wide range of substrates to give the desired products in good yields (up to 94%) with excellent enantioselectivities (up to 99% ee) and diastereoselectivities (up to 99:1).