Multicomponent Strategy to Pyrazolo[3,4-e]indolizine Derivatives under Microwave Irradiation

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• 作者：Jian-Jun Wang ; Xian Feng ; Zhan Xun ; Da-Qing Shi ; Zhi-Bin Huang
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：August 21, 2015
• 年：2015
• 卷：80
• 期：16
• 页码：8435-8442
• 全文大小：368K
• ISSN：1520-6904

文摘

A simple and efficient one-pot construction of pyrazolo[3,4-e]indolizine derivatives via a diethylamine-catalyzed three-component domino reaction of arylglyoxals, cyclic 1,3-diones, and 5-aminopyrazoles under microwave irradiation is described. In this one-pot transformation, seven bonds and two new rings are efficiently formed. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional recrystallization or chromatography purification methods.