Polysaccharides of Trametes versicolor Improve Bone Properties in Diabetic Rats

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• 作者：Chung-Hwan Chen ; Lin Kang ; Hui-Chen Lo ; Tai-Hao Hsu ; Fang-Yi Lin ; Yi-Shan Lin ; Zai-Jie Wang ; Shih-Tse Chen ; Chwan-Li Shen
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：October 28, 2015
• 年：2015
• 卷：63
• 期：42
• 页码：9232-9238
• 全文大小：279K
• ISSN：1520-5118

文摘

This study investigates the effects of Trametes versicolor (L.:Fr.) Pil谩t (TVP, also known as Yunzhi) on bone properties in diabetic rats. Forty-five male Wistar rats (8 weeks old) were fed either a chow diet (control) or a high-fat diet throughout the study period of 28 days. Animals in the high-fat-diet group were injected with nicotinamide and streptozotocin to induce diabetes mellitus (DM). The DM rats were divided into a group receiving distilled water (vehicle) and another group receiving TVP at 0.1 g/kg weight by gavage. Relative to the vehicle group, TVP gavage lowered postprandial blood sugar (225 卤 18 mg/dL for TVP vs 292 卤 15 mg/dL for vehicle, p < 0.001) on day 26. Compared to the vehicle group, TVP mitigated DM-induced bone deterioration as determined by increasing bone volume of proximal tibia (22.8 卤 1.4% for TVP vs 16.8 卤 1.3% for vehicle, p = 0.003), trabecular number (p = 0.011), and femoral bone strength (11% in maximal load, 22% in stiffness, 14% in modulus, p < 0.001), and by reducing loss of femoral cortical porosity by 25% (p < 0.001). Our study demonstrates the protective effect of TVP on bone properties was mediated through, in part, the improvement of hyperglycemic control in DM animals.