Gold(I)-Catalyzed Regioselective Inter-/Intramolecular Addition Cascade of Di- and Triynes for Direct Construction of Substituted Naphthalenes
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- 作者：Saori Naoe ; Yamato Suzuki ; Kimio Hirano ; Yusuke Inaba ; Shinya Oishi ; Nobutaka Fujii ; Hiroaki Ohno
- 刊名：The Journal of Organic Chemistry
- 出版年：2012
- 出版时间：June 1, 2012
- 年：2012
- 卷：77
- 期：11
- 页码：4907-4916
- 全文大小：499K
- 年卷期：v.77,no.11(June 1, 2012)
- ISSN：1520-6904
文摘
The gold-catalyzed cascade intermolecular addition鈥搃ntramolecular carbocyclization reaction of dialkynylbenzenes was developed. In this reaction, regioselective addition of an external nucleophile toward the terminal alkyne and subsequent 6-endo-dig cyclization proceeded to give the 1,3-disubstituted naphthalenes in good yields. The direct synthesis of disubstituted chrysenes via a gold-catalyzed addition and double cyclization cascade using a triyne-type substrate was also achieved.