Modification of Silicone Elastomer with Zwitterionic Silane for Durable Antifouling Properties

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• 作者：Shiou-Bang Yeh ; Chien-Sheng Chen ; Wen-Yih Chen ; Chun-Jen Huang
• 刊名：Langmuir
• 出版年：2014
• 出版时间：September 30, 2014
• 年：2014
• 卷：30
• 期：38
• 页码：11386-11393
• 全文大小：430K
• ISSN：1520-5827

文摘

Biofouling on medical devices generally causes adverse complications, such as thrombosis, infection, and pathogenic calcification. Silicone is a widely used material for medical applications. Its surface modification typically encounters undesirable 鈥渉ydrophobic recovery鈥? leading to deterioration of surface engineering. In this study, we developed a stable superhydrophilic zwitterionic interface on polydimethylsiloxane (PDMS) elastomer by covalent silanization of sulfobetaine silane (SBSi) to resist nonspecific adsorption of bacteria, proteins, and lipids. SBSi is a zwitterionic organosilane assembly, enabling resisting surface reconstruction by forming a cross-linked network and polar segregation. Surface elemental composition was confirmed by X-ray photoelectron spectroscopy (XPS), and the long-term stability of modification was accessed using a contact angle goniometer. The biofouling tests were carried out by exposing substrates to bacterial, protein, and lipid solutions, revealing the excellent bioinertness of SBSi-tailored PDMS, even after 30 day storage in ambient. For the real-world application, we modified commercially available silicone hydrogel contact lenses with developed zwitterionic silane, presenting its antibacterial adhesion property. Moreover, the cytotoxicity of SBSi was accessed with NIH-3T3 fibroblast by the MTT assay, showing negligible cytotoxicity up to a concentration of 5 mM. Consequently, the strategy of surface engineering in this work can effectively retard the 鈥渉ydrophobic recovery鈥?occurrence and can be applied to other silicone-based medical devices in a facile way.