Ethanolic Extracts and Isolated Compounds from Small-Leaf Grape (Vitis thunbergii var. taiwaniana) with Antihypertensive Activities

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• 作者：Yin-Shiou Lin ; Yeh-Lin Lu ; Guei-Jane Wang ; Lih-Geeng Chen ; Chi-Luan Wen ; Wen-Chi Hou
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2012
• 出版时间：August 1, 2012
• 年：2012
• 卷：60
• 期：30
• 页码：7435-7441
• 全文大小：384K
• 年卷期：v.60,no.30(August 1, 2012)
• ISSN：1520-5118

文摘

This study aimed to investigate the antihypertensive effects of ethanolic extracts (EE) and compounds isolated from the small-leaf grape (Vitis thunbergii var. taiwaniana, VTT). The highest antiangiotensin-converting enzyme (anti-ACE) was found in stem-EE (IC₅₀ was 69.5 渭g/mL). In spontaneously hypertensive rats (SHRs), stem-EE effectively reduced blood pressure 24 h after administration of a single oral dose or when administered daily for 4 weeks. The isolated compounds, including (+)-vitisin A, ampelopsin C, and (+)-蔚-viniferin, were shown to have anti-ACE and vasodilating effects against phenylephrine-induced tensions in an endothelium-intact aortic ring, with (+)-vitisin A being the most effective compound. Compared to control rats, SHRs showed significantly reduced systolic and diastolic blood pressures 24 h after a single oral dose of (+)-vitisin A (10 mg/kg) or captopril (2 mg/kg). These results suggest that the development of functional foods with VTT extracts may be beneficial for regulating blood pressure.

Keywords:

angiotensin converting enzyme; aortic ring relaxation; blood pressure; spontaneously hypertensive rat (SHR); Vitis thunbergii var. taiwaniana (VTT); (+)-vitisin A