Chemical Constituents of a Marine Fungus, Arthrinium sacchari
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- 作者：Mariko Tsukada ; Miyuki Fukai ; Kazuhiko Miki ; Takeshi Shiraishi ; Toshihiro Suzuki ; Kazuto Nishio ; Takashi Sugita ; Masahiro Ishino ; Kaoru Kinoshita ; Kunio Takahashi ; Motoo Shiro ; Kiyotaka Koyama
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：July 22, 2011
- 年：2011
- 卷：74
- 期：7
- 页码：1645-1649
- 全文大小：791K
- 年卷期：v.74,no.7(July 22, 2011)
- ISSN：1520-6025
文摘
Three new diterpenes, myrocin D (1), libertellenone E (2), and libertellenone F (3), and a new isocoumarin, decarboxyhydroxycitrinone (4), were isolated from the marine fungus Arthrinium sacchari, together with three known compounds (5鈥?b>7). The structures of 1鈥?b>4 were elucidated from spectroscopic data (NMR, MS, IR), and the absolute configurations of 1鈥?b>3 were determined by X-ray diffraction analysis. The antiangiogenic activity of these compounds was evaluated by measuring their antiproliferation effects on human umbilical vein endothelial cells (HUVECs) and human umbilical artery endothelial cells (HUAECs). Compounds 4鈥?b>7 showed inhibitory activity.