Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07

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• 作者：Shengxin Cai ; Shiwei Sun ; Huinan Zhou ; Xianglan Kong ; Tianjiao Zhu ; Dehai Li ; Qianqun Gu
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1106-1110
• 全文大小：761K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A鈭扖 (1鈭?b>3) and prenylcandidusins A鈭扖 (5鈭?b>7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4鈥测€?dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8鈭?b>15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC₅₀ 1.53鈭?0.90 渭M), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC₅₀ of 2.70 and 1.57 渭M, respectively).