Iridium(III)-Catalyzed Tandem [3 + 2] Annulation: Synthesis of Spirocyclic Phosphoramide Derivatives

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• 作者：Shuai-Shuai Li ; Lin Wu ; Liu Qin ; Yu-Qin Zhu ; Fu Su ; Yan-Jun Xu ; Lin Dong
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：18
• 期：17
• 页码：4214-4217
• 全文大小：366K
• 年卷期：0
• ISSN：1523-7052

文摘

A highly efficient iridium(III)-catalyzed C–H activation/tandem Grignard-type [3 + 2] annulation process was developed for the synthesis of novel spirocyclic phosphoramide derivatives. Compared with other transition-metal catalysts, [Cp*IrCl₂]₂ exhibited favorite efficiency and best selectivity in this cascade reaction. The strategy could be applied to further construct more complex heterocyclic compounds.