Constituents of the Roots of Clausena lansium and Their Potential Anti-inflammatory Activity

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• 作者：De-Yang Shen ; Yu-Yi Chan ; Tsong-Long Hwang ; Shin-Hun Juang ; Shiow-Chyn Huang ; Ping-Chung Kuo ; Tran Dinh Thang ; E-Jian Lee ; Amooru G. Damu ; Tian-Shung Wu
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：May 23, 2014
• 年：2014
• 卷：77
• 期：5
• 页码：1215-1223
• 全文大小：368K
• 年卷期：v.77,no.5(May 23, 2014)
• ISSN：1520-6025

文摘

Eight new carbazole alkaloids, claulamines C (1), D (2), and E (5) and clausenalines B鈥揊 (3, 4, 6鈥?b>8), four new coumarins, clausemarins A鈥揇 (9鈥?b>12), and 43 known compounds were isolated from the roots of Clausena lansium. The structures of the new compounds were established on the basis of 2D-NMR spectroscopic analysis, and their absolute configurations were established from their ECD spectra. The configuration of wampetin was revised as E using a NOESY experiment. Most of the isolated compounds were evaluated for their potential anti-inflammatory activity. The results showed that compounds 9, 13鈥?b>18, and 20鈥?b>22 exhibited strong inhibition of superoxide anion generation with IC₅₀ values ranging from 1.9 to 8.4 渭M, while compounds 18, 19, and 21 inhibited elastase release with IC₅₀ values in the range from 2.0 to 6.9 渭M.