Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols

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• 作者：Latisha R. Jefferies ; Silas P. Cook
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：April 4, 2014
• 年：2014
• 卷：16
• 期：7
• 页码：2026-2029
• 全文大小：291K
• 年卷期：v.16,no.7(April 4, 2014)
• ISSN：1523-7052

文摘

A simple, iron-based catalytic system allows for the inter- and intramolecular arylation of unactivated secondary alcohols. This transformation expands the substrate scope beyond the previously required activated alcohols and proceeds under mild reaction conditions, tolerating air and moisture. Furthermore, the use of an enantioenriched secondary alcohol provides an enantioenriched product for the intramolecular reaction, thereby offering a convenient approach to nonracemic products.