α-Helix Stabilization within a Peptide Dendrimer
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- 作者：Sacha Javor ; Antonino Natalello ; Silvia Maria Doglia ; Jean-Louis Reymond
- 刊名：Journal of the American Chemical Society
- 出版年：2008
- 出版时间：December 24, 2008
- 年：2008
- 卷：130
- 期：51
- 页码：17248-17249
- 全文大小：202K
- 年卷期：v.130,no.51(December 24, 2008)
- ISSN：1520-5126
文摘
The α-helical second generation peptide dendrimer of sequence (AcAMEA)4(KKLME)2KMKLA is more stable than the corresponding linear peptide AcAMEAAKLMEAMKLA toward pH-induced unfolding and temperature-induced intermolecular aggregation. The effect is interpreted in terms of an α-helix spanning across two successive branching points of the dendrimer. This stabilization effect is unprecedented and opens the way to folded dendritic analogues of proteins using natural amino acids only.