The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids
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- 作者：Erika Cerutti ; Alessandra Viale ; Carlo Nervi ; Roberto Gobetto ; Silvio Aime
- 刊名：Journal of Physical Chemistry A
- 出版年：2015
- 出版时间：November 19, 2015
- 年：2015
- 卷：119
- 期：46
- 页码：11271-11279
- 全文大小：438K
- ISSN：1520-5215
文摘
A series of dehydroamino acids endowed with different protective groups at the amino and carboxylate moieties and with different substituents at the double bond have been reacted with parahydrogen. The observed ParaHydrogen Induced Polarization (PHIP) effects in the 1H NMR spectra are strongly dependent on the amino protecting group. DFT calculations allowed us to establish a relationship between the structures of the reaction intermediates (whose energies depend on the amido substitution) and the observed PHIP patterns.