Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona

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• 作者：Krishnendu Saha ; Mehran Rahimi ; Mahdieh Yazdani ; Sung Tae Kim ; Daniel F. Moyano ; Singyuk Hou ; Ridhha Das ; Rubul Mout ; Farhad Rezaee ; Morteza Mahmoudi ; Vincent M. Rotello
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：April 26, 2016
• 年：2016
• 卷：10
• 期：4
• 页码：4421-4430
• 全文大小：771K
• 年卷期：0
• ISSN：1936-086X

文摘

Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages.