Size-Dependent Programming of the Dynamic Range of Graphene Oxide鈥揇NA Interaction-Based Ion Sensors

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• 作者：Huan Zhang ; Sisi Jia ; Min Lv ; Jiye Shi ; Xiaolei Zuo ; Shao Su ; Lianhui Wang ; Wei Huang ; Chunhai Fan ; Qing Huang
• 刊名：Analytical Chemistry
• 出版年：2014
• 出版时间：April 15, 2014
• 年：2014
• 卷：86
• 期：8
• 页码：4047-4051
• 全文大小：306K
• 年卷期：v.86,no.8(April 15, 2014)
• ISSN：1520-6882

文摘

Graphene oxide (GO) is widely used in biosensors and bioimaging because of its high quenching efficiency, facile chemical conjugation, unique amphiphile property, and low cost for preparation. However, the nanometer size effect of GO on GO鈥揇NA interaction has long been ignored and remains unknown. Here we examined the nanometer size effect of GO on GO鈥揇NA interactions. We concluded that GO of 200 nm (lateral nanometer size) possessed the highest fluorescence quenching efficiency whereas GO of 40 nm demonstrated much weaker ability to quench the fluorescence. We employed the nanometer size effect of GO to program the dynamic ranges and sensitivity of mercury sensors. Three dynamic ranges (1 to 40 nM, 1 to 15 nM, and 0.1 to 5 nM) were obtained with this size modulation. The sensitivity (slope of titration curve) was programmed from 15.3 卤 1.27 nM^鈥? to 106.2 卤 3.96 nM^鈥?.