Lewis Acid Catalyzed Tandem Polycyclization of Internal Alkynols and Vinyl Azides

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• 作者：Hai Xiao Siyang ; Xiao Yue Ji ; Xu Rui Wu ; Xin Yan Wu ; Pei Nian Liu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：17
• 期：21
• 页码：5220-5223
• 全文大小：368K
• ISSN：1523-7052

文摘

A novel Lewis acid catalyzed tandem cyclization reaction of internal alkynols and vinyl azides has been achieved to afford a series of products containing a pyran-based indeno[1,2-c]isochromene scaffold in moderate to high yields. This tandem polycyclization protocol provides a straightforward entry to construct the complex polycyclic skeleton through cycloisomerization, formal [4 + 2] cycloaddition, and an elimination process.