Mollemycin A: An Antimalarial and Antibacterial Glyco-hexadepsipeptide-polyketide from an Australian Marine-Derived Streptomyces sp. (CMB-M0244)

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• 作者：Ritesh Raju ; Zeinab G. Khalil ; Andrew M. Piggott ; Antje Blumenthal ; Donald L. Gardiner ; Tina S. Skinner-Adams ; Robert J. Capon
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 21, 2014
• 年：2014
• 卷：16
• 期：6
• 页码：1716-1719
• 全文大小：222K
• 年卷期：v.16,no.6(March 21, 2014)
• ISSN：1523-7052

文摘

A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C₃ Marfey鈥檚 analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC₅₀ 10鈥?0 nM) and drug-sensitive (3D7; IC₅₀ 7 nM) and multidrug-resistant (Dd2; IC₅₀ 9 nM) clones of the malaria parasite Plasmodium falciparum.