Indoleamine 2,3-Dioxygenase Inhibitors Isolated from the Sponge Xestospongia vansoesti: Structure Elucidation, Analogue Synthesis, and Biological Activity
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- 作者：Ryan M. Centko ; Anne Stein酶 ; Federico I. Rosell ; Brian O. Patrick ; Nicole de Voogd ; A. Grant Mauk ; Raymond J. Andersen
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：December 19, 2014
- 年：2014
- 卷：16
- 期：24
- 页码：6480-6483
- 全文大小：284K
- ISSN：1523-7052
文摘
Two new IDO inhibitory meroterpenoids, xestolactone A (1) and xestosaprol O (2), have been isolated from the sponge Xestospongia vansoesti. Xestolactone A (1) has an unprecedented degraded meroterpenoid carbon skeleton. A short synthesis of the xestosaprol O (2) analogues 3 and 4 features the application of a rarely used photochemical coupling reaction. Synthetic analogue 3 is 鈭?0 times more potent than the inspirational natural product 2.