Contrasting the Surface and Bulk Properties of Anhydrate and Dehydrated Hydrate Materials

详细信息    查看全文

• 作者：Masahiro Yamauchi ; Eun Hee Lee ; Andrew Otte ; Stephen R. Byrn ; M. Teresa Carvajal
• 刊名：Crystal Growth & Design
• 出版年：2011
• 出版时间：March 2, 2011
• 年：2011
• 卷：11
• 期：3
• 页码：692-698
• 全文大小：915K
• 年卷期：v.11,no.3(March 2, 2011)
• ISSN：1528-7505

文摘

Surface and bulk characterization of niclosamide and naproxen sodium between anhydrate and dehydrated hydrate were investigated. A comprehensive solid-state characterization was conducted using X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), and scanning electron microscopy (SEM) for the identification and determination of physical properties of the materials. Surface properties were addressed by evaluating the various forms: by inverse gas chromatography (IGC) and water sorption tendency (dynamic vapor sorption, VTI). The XRPD, DSC, and TGA data show slight or no differences between anhydrate and dehydrated hydrate. However, the SEM, IGC, and water vapor sorption isotherms results provided evidence of the heterogeneity of surface for both compounds. The SEM microphotographs clearly showed the rugosity of the powders. Niclosamide dehydrated hydrate showed a higher dispersive surface energy and higher rate of moisture sorption than the correspondent anhydrate, whereas the opposite was observed for naproxen sodium. The dispersive surface energy is a complementary approach to the existing and traditional robust characterization techniques. This study has provided an insight of the bulk and surface properties of the anhydrate and the dehydrated hydrate forms of niclosamide and naproxen sodium.