Soft Hydrogels from Nanotubes of Poly(ethylene oxide)−Tetraphenylalanine Conjugates Prepared by Click Chemistry

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• 作者：Nadia Tzokova ; Christine M. Fernyhough ; Paul D. Topham ; Nicolas Sandon ; Dave J. Adams ; Michael F. Butler ; Steven P. Armes ; Anthony J. Ryan
• 刊名：Langmuir
• 出版年：2009
• 出版时间：February 17, 2009
• 年：2009
• 卷：25
• 期：4
• 页码：2479-2485
• 全文大小：228K
• 年卷期：v.25,no.4(February 17, 2009)
• ISSN：1520-5827

文摘

A new poly(ethylene oxide)−tetraphenylalanine polymer−peptide conjugate has been prepared via a “click” reaction between an alkyne-modified peptide and an azide-terminated PEO oligomer. Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer−peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel β-sheets and π−π-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL⁻¹. Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer−peptide conjugate concentration, as expected.