Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces

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• 作者：Steven C. Hayden ; Gengxiang Zhao ; Krishnendu Saha ; Ronnie L. Phillips ; Xiaoning Li ; Oscar R. Miranda ; Vincent M. Rotello ; Mostafa A. El-Sayed ; Ingeborg Schmidt-Krey ; Uwe H. F. Bunz
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：April 25, 2012
• 年：2012
• 卷：134
• 期：16
• 页码：6920-6923
• 全文大小：391K
• 年卷期：v.134,no.16(April 25, 2012)
• ISSN：1520-5126

文摘

Cationic monolayer-protected gold nanoparticles (AuNPs) with sizes of 6 or 2 nm interact with the cell membranes of Escherichia coli (Gram鈭? and Bacillus subtilis (Gram+), resulting in the formation of strikingly distinct AuNP surface aggregation patterns or lysis depending upon the size of the AuNPs. The aggregation phenomena were investigated by transmission electron microscopy and UV鈥搗is spectroscopy. Upon proteolytic treatment of the bacteria, the distinct aggregation patterns disappeared.