Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification

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• 作者：Takashi Ouchi ; Robbie J. Mutton ; Victor Rojas ; Daniel E. Fitzpatrick ; David G. Cork ; Claudio Battilocchio ; Steven V. Ley
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2016
• 出版时间：April 4, 2016
• 年：2016
• 卷：4
• 期：4
• 页码：1912-1916
• 全文大小：331K
• ISSN：2168-0485

文摘

A solvent-free approach to intensification of chemical processes is reported. This concept, in which reactions are carried out solvent-free, without the need for further downstream processing, was highlighted first with a full reduction of ethyl nicotinate to ethylpiperidine-3-carboxylate under continuous flow conditions. Using a small footprint reactor, a throughput of 26.4 g h^–1 was achieved. Similarly, this approach was used for the telescoped two-step synthesis of 2-propyl phenol (productivity 120 g h^–1) and 2-propyl cyclohexanone (productivity 30 g h^–1), starting from the commercially available allyl phenol ether via Claisen rearrangement and subsequent reduction.