Chrysosporide, a Cyclic Pentapeptide from a New Zealand Sample of the Fungus Sepedonium chrysospermum

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• 作者：Maya I. Mitova ; Blair G. Stuart ; Grace H. Cao ; John W. Blunt ; Anthony L. J. Cole ; Murray H. G. Munro
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：69
• 期：10
• 页码：1481 - 1484
• 全文大小：71K
• 年卷期：v.69,no.10(October 2006)
• ISSN：1520-6025

文摘

A new cyclic pentapeptide, chrysosporide (1), was isolated from a New Zealand sample of the mycoparasitic fungusSepedonium chrysospermum by bioactivity-guided fractionation. The planar structure was deduced by detailedspectroscopic analysis, and the absolute configurations of the amino acid residues were defined by Marfey's method.As both enantiomers of Leu occurred in chrysosporide, molecular mechanics calculations were applied to the analysisto distinguish between the possible structural isomers. Only the lowest energy conformers of the cyclo-(L-Val-D-Ala-L-Leu-L-Leu-D-Leu) isomer were in agreement with the observed NOEs, suggesting that this was the most probableamino acid sequence for chrysosporide (1).