Fluostatins I鈥揔 from the South China Sea-Derived Micromonospora rosaria SCSIO N160

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• 作者：Wenjun Zhang ; Zhong Liu ; Sumei Li ; Yongzhi Lu ; Yuchan Chen ; Haibo Zhang ; Guangtao Zhang ; Yiguang Zhu ; Gaiyun Zhang ; Weimin Zhang ; Jinsong Liu ; Changsheng Zhang
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：November 26, 2012
• 年：2012
• 卷：75
• 期：11
• 页码：1937-1943
• 全文大小：364K
• 年卷期：v.75,no.11(November 26, 2012)
• ISSN：1520-6025

文摘

The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I鈥揔 (1鈥?b>3), were isolated from the culture of M. rosaria SCSIO N160, together with six known compounds, fluostatins C鈥揊 (4鈥?b>7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 渭g/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC₅₀ 0.09 渭M) and MCF-7 (IC₅₀ 0.17 渭M).