Stability of DNA Origami Nanostructure under Diverse Chemical Environments

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• 作者：Hyojeong Kim ; Sumedh P. Surwade ; Anna Powell ; Christina O鈥橠onnell ; Haitao Liu
• 刊名：Chemistry of Materials
• 出版年：2014
• 出版时间：September 23, 2014
• 年：2014
• 卷：26
• 期：18
• 页码：5265-5273
• 全文大小：749K
• ISSN：1520-5002

文摘

We report the effect of chemical and physical treatments on the structural stability of DNA origami nanostructures. Our result shows that DNA nanostructure maintains its shape under harsh processing conditions, including thermal annealing up to 200 掳C for 10 min, immersing in a wide range of organic solvents for up to 24 h, brief exposure to alkaline aqueous solutions, and 5 min exposure to UV/O₃. Our result suggests that the application window of DNA nanostructure is significantly wider than previously believed.