Ultrahigh 19F Loaded Cu1.75S Nanoprobes for Simultaneous 19F Magnetic Resonance Imaging and Photothermal Therapy

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• 作者：Hongli Chen ; Manli Song ; Juan Tang ; Gaofei Hu ; Suying Xu ; Zhide Guo ; Nannan Li ; Jiabin Cui ; Xianzhong Zhang ; Xiaoyuan Chen ; Leyu Wang
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：January 26, 2016
• 年：2016
• 卷：10
• 期：1
• 页码：1355-1362
• 全文大小：529K
• ISSN：1936-086X

文摘

¹⁹F magnetic resonance imaging (MRI) is a powerful noninvasive, sensitive, and accurate molecular imaging technique for early diagnosis of diseases. The major challenge of ¹⁹F MRI is signal attenuation caused by the reduced solubility of probes with increased number of fluorine atoms and the restriction of molecular mobility. Herein, we present a versatile one-pot strategy for the fabrication of a multifunctional nanoprobe with high ¹⁹F loading (～2.0 × 10^8?19F atoms per Cu_1.75S nanoparticle). Due to the high ¹⁹F loading and good molecular mobility that results from the small particle size (20.8 ± 2.0 nm) and ultrathin polymer coating, this nanoprobe demonstrates ultrahigh ¹⁹F MRI signal. In vivo tests show that this multifunctional nanoprobe is suitable for ¹⁹F MRI and photothermal therapy. This versatile fabrication strategy has also been readily extended to other single-particle nanoprobes for ablation and sensitive multimodal imaging.