A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides

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• 作者：Emilie Racine ; Florian Monnier ; Jean-Pierre Vors ; Marc Taillefer
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：June 3, 2011
• 年：2011
• 卷：13
• 期：11
• 页码：2818-2821
• 全文大小：734K
• 年卷期：v.13,no.11(June 3, 2011)
• ISSN：1523-7052

文摘

The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.