Stelleralides A鈥揅, Novel Potent Anti-HIV Daphnane-Type Diterpenoids from Stellera chamaejasme L.

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• 作者：Yoshihisa Asada ; Aya Sukemori ; Takashi Watanabe ; Kuber J. Malla ; Takafumi Yoshikawa ; Wei Li ; Kazuo Koike ; Chin-Ho Chen ; Toshiyuki Akiyama ; Keduo Qian ; Kyoko Nakagawa-Goto ; Susan L. Morris-Natschke ; Kuo-Hsiung Lee
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：June 3, 2011
• 年：2011
• 卷：13
• 期：11
• 页码：2904-2907
• 全文大小：728K
• 年卷期：v.13,no.11(June 3, 2011)
• ISSN：1523-7052

文摘

Three novel 1-alkyldaphnane-type diterpenes, stelleralides A鈥揅 (4鈥?b>6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4鈥?b>6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC₉₀ 0.40 nM) with the lowest cytotoxicity (IC₅₀ 4.3 渭M) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.