Viridaphin A1 Glucoside, a Green Pigment Possessing Cytotoxic and Antibacterial Activity from the Aphid Megoura crassicauda

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• 作者：Mitsuyo Horikawa ; To-sho Hoshiyama ; Masako Matsuzawa ; Takanori Shugyo ; Masami Tanaka ; Shinya Suzuki ; Masao Sato ; Takuya Ito ; Yoshinori Asakawa ; Hiroto Kaku ; Takeshi Nishii ; Makoto Inai ; Shigeru Takahashi ; Tetsuto Tsunoda
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：August 26, 2011
• 年：2011
• 卷：74
• 期：8
• 页码：1812-1816
• 全文大小：794K
• 年卷期：v.74,no.8(August 26, 2011)
• ISSN：1520-6025

文摘

A green pigment, viridaphin A₁ glucoside (1), was isolated from the green aphid Megoura crassicauda. One- and two-dimensional NMR spectrometric analyses of 1 and its aglycone established the structure as an octacyclic compound. Viridaphin A₁ glucoside exhibited cytotoxicity against HL-60 human tumor cells with an IC₅₀ of 23 渭M and antibacterial activity against Bacillus subtilis NBRC 3134 with a minimum inhibitory concentration of 10.0 渭g/mL. These results suggested that aphid pigments may protect aphids from invasive species, including viruses and bacteria.