Gliotoxin Analogues from a Marine-Derived Fungus, Penicillium sp., and Their Cytotoxic and Histone Methyltransferase Inhibitory Activities

详细信息    查看全文

• 作者：Yi Sun ; Kentaro Takada ; Yasushi Takemoto ; Minoru Yoshida ; Yuichi Nogi ; Shigeru Okada ; Shigeki Matsunaga
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：January 27, 2012
• 年：2012
• 卷：75
• 期：1
• 页码：111-114
• 全文大小：216K
• 年卷期：v.75,no.1(January 27, 2012)
• ISSN：1520-6025

文摘

Seven gliotoxin-related compounds were isolated from the fungus Penicillium sp. strain JMF034, obtained from deep sea sediments of Suruga Bay, Japan. These included two new metabolites, bis(dethio)-10a-methylthio-3a-deoxy-3,3a-didehydrogliotoxin (1) and 6-deoxy-5a,6-didehydrogliotoxin (2), and five known metabolites (3鈥?b>7). The structures of the new compounds were elucidated by analysis of spectroscopic data and the application of the modified Mosher鈥檚 analysis. All of the compounds exhibited cytotoxic activity, whereas compounds containing a disulfide bond showed potent inhibitory activity against histone methyltransferase (HMT) G9a. None of them inhibited HMT SET7/9.