Biosensor Based on Ultrasmall MoS2 Nanoparticles for Electrochemical Detection of H2O2 Released by Cells at the Nanomolar Level

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• 作者：Tanyuan Wang ; Haichuan Zhu ; Junqiao Zhuo ; Zhiwei Zhu ; Pagona Papakonstantinou ; Gennady Lubarsky ; Jian Lin ; Meixian Li
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：November 5, 2013
• 年：2013
• 卷：85
• 期：21
• 页码：10289-10295
• 全文大小：353K
• 年卷期：v.85,no.21(November 5, 2013)
• ISSN：1520-6882

文摘

Monodispersed surfactant-free MoS₂ nanoparticles with sizes of less than 2 nm were prepared from bulk MoS₂ by simple ultrasonication and gradient centrifugation. The ultrasmall MoS₂ nanoparticles expose a large fraction of edge sites, along with their high surface area, which lead to attractive electrocatalytic activity for reduction of H₂O₂. An extremely sensitive H₂O₂ biosensor based on MoS₂ nanoparticles with a real determination limit as low as 2.5 nM and wide linear range of 5 orders of magnitude was constructed. On the basis of this biosensor, the trace amount of H₂O₂ released from Raw 264.7 cells was successfully recorded, and an efficient glucose biosensor was also fabricated. Since H₂O₂ is a byproduct of many oxidative biological reactions, this work serves as a pathway for the application of MoS₂ in the fields of electrochemical sensing and bioanalysis.