Rhodium-Catalyzed Annulation of Primary Benzylamine with α-Diazo Ketone toward Isoquinoline

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• 作者：Haoke Chu ; Peiran Xue ; Jin-Tao Yu ; Jiang Cheng
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：81
• 期：17
• 页码：8009-8013
• 全文大小：378K
• 年卷期：0
• ISSN：1520-6904

文摘

Rhodium-catalyzed annulation of commercially available primary benzylamine with α-diazo ketone was developed, leading to isoquinolines in moderate to good yields. This procedure features the employment of primary benzylamine as starting material as well as high selectivity in the 3- and 4- position of isoquinoline, generating a key compliment to the previously developed annulation with internal alkyne.