One-Pot Access to a Library of Structurally Diverse Nicotinamide Derivatives via a Three-Component Formal Aza [3 + 3] Cycloaddition

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• 作者：Giammarco Tenti ; M^a Teresa Ramos ; J. Carlos Men茅ndez
• 刊名：ACS Combinatorial Science
• 出版年：2012
• 出版时间：October 8, 2012
• 年：2012
• 卷：14
• 期：10
• 页码：551-557
• 全文大小：303K
• 年卷期：v.14,no.10(October 8, 2012)
• ISSN：2156-8944

文摘

The three-component formal [3 + 3] aza-annulation between chalcones, 尾-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to excellent yields of highly substituted nicotinamides or their fused derivatives. This transformation leads to the formation of one C鈥揅 and two C鈥揘 bonds in a single synthetic operation and involves up to five individual steps.

Keywords:

multicomponent reactions; pyridine synthesis; [3 + 3]aza-annulations