Identification of Ostruthin from Peucedanum ostruthium Rhizomes as an Inhibitor of Vascular Smooth Muscle Cell Proliferation
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- 作者：Helge Joa ; Sylvia Vogl ; Atanas G. Atanasov ; Martin Zehl ; Thomas Nakel ; Nanang Fakhrudin ; Elke H. Heiss ; Paolo Picker ; Ernst Urban ; Christoph Wawrosch ; Johannes Saukel ; Gottfried Reznicek ; Brigitte Kopp ; Verena M. Dirsch
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：June 24, 2011
- 年：2011
- 卷：74
- 期：6
- 页码：1513-1516
- 全文大小：722K
- 年卷期：v.74,no.6(June 24, 2011)
- ISSN：1520-6025
文摘
Inhibition of vascular smooth muscle cell (VSMC) proliferation is of substantial interest in combating cardiovascular disease. A dichloromethane extract from the rhizomes of Peucedanum ostruthium, a traditionally used Austrian medicinal plant with anti-inflammatory properties, was examined for a putative antiproliferative activity in rat aortic VSMC. This extract inhibited serum (10%)-induced VSMC proliferation concentration dependently. Further identification and biological testing of its major constituents revealed that the coumarin ostruthin (7) is the major antiproliferative substance. In summary, a new bioactivity of P. ostruthium rhizomes is described, and 7 has been identified as the responsible compound.