Tools for the Microbiome: Nano and Beyond

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• 作者：Julie S. Biteen ; Paul C. Blainey ; Zoe G. Cardon ; Miyoung Chun ; George M. Church ; Pieter C. Dorrestein ; Scott E. Fraser ; Jack A. Gilbert ; Janet K. Jansson ; Rob Knight ; Jeff F. Miller ; Aydogan Ozcan ; Kimberly A. Prather ; Stephen R. Quake ; Edward G. Ruby ; Pamela A. Silver ; Sharif Taha ; Ger van den Engh ; Paul S. Weiss ; Gerard C. L. Wong ; Aaron T. Wright ; Thomas D. Young
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：January 26, 2016
• 年：2016
• 卷：10
• 期：1
• 页码：6-37
• 全文大小：1305K
• ISSN：1936-086X

文摘

The microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. These technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.