Transfer Hydro-dehalogenation of Organic Halides Catalyzed by Ruthenium(II) Complex

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• 作者：Tingjie You ; Zhenrong Wang ; Jiajia Chen ; Yuanzhi Xia
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：82
• 期：3
• 页码：1340-1346
• 全文大小：533K
• ISSN：1520-6904

文摘

A simple and efficient Ru(II)-catalyzed transfer hydro-dehalogenation of organic halides using 2-propanol solvent as the hydride source was reported. This methodology is applicable for hydro-dehalogenation of a variety of aromatic halides and α-haloesters and amides without additional ligand, and quantitative yields were achieved in many cases. The potential synthetic application of this method was demonstrated by efficient gram-scale transformation with catalyst loading as low as 0.5 mol %.