Molecular Library Synthesis Using Complex Substrates: Expanding the Framework of Triterpenoids

详细信息    查看全文

• 作者：Vasily A. Ignatenko ; Yong Han ; Gregory P. Tochtrop
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：January 18, 2013
• 年：2013
• 卷：78
• 期：2
• 页码：410-418
• 全文大小：428K
• 年卷期：v.78,no.2(January 18, 2013)
• ISSN：1520-6904

文摘

The remodeling of a natural product core framework by means of diversity-oriented synthesis (DOS) is a valuable approach to access diverse/biologically relevant chemical space and to overcome the limitations of combinatorial-type compounds. Here we provide proof of principle and a thorough conformational analysis for a general strategy whereby the inherent complexity of a starting material is used to define the regio- and stereochemical outcomes of reactions in chemical library construction. This is in contrast to the traditional DOS logic employing reaction development and catalysis to drive library diversity.