Agelamadins C鈥揈, Bromopyrrole Alkaloids Comprising Oroidin and 3-Hydroxykynurenine from a Marine Sponge Agelas sp.

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• 作者：Taishi Kusama ; Naonobu Tanaka ; Kanae Sakai ; Tohru Gonoi ; Jane Fromont ; Yoshiki Kashiwada ; Jun鈥檌chi Kobayashi
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：October 3, 2014
• 年：2014
• 卷：16
• 期：19
• 页码：5176-5179
• 全文大小：334K
• ISSN：1523-7052

文摘

Three structurally unique bromopyrrole alkaloids, agelamadins C鈥揈 (1鈥?b>3), were isolated from a marine sponge Agelas sp. Agelamadin C (1) possesses a hybrid structure of oroidin and 3-hydroxykynurenine connected through a dihydro-1,4-oxazine moiety. Agelamadins D (2) and E (3) are a C-9/C-10 diastereomer and a 10-epimer of 1, respectively. The structures of 1鈥?b>3 were elucidated on the basis of spectroscopic analysis as well as application of a PGME method and a TDDFT ECD calculation. Antimicrobial activity of 1鈥?b>3 was evaluated.