Verticilactam, a New Macrolactam Isolated from a Microbial Metabolite Fraction Library
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- 作者：Toshihiko Nogawa ; Akiko Okano ; Shunji Takahashi ; Masakazu Uramoto ; Hideaki Konno ; Tamio Saito ; Hiroyuki Osada
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：October 15, 2010
- 年：2010
- 卷：12
- 期：20
- 页码：4564-4567
- 全文大小：146K
- 年卷期：v.12,no.20(October 15, 2010)
- ISSN：1523-7052
文摘
Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a β-keto-amide moiety.