Robust Turn Structures in 伪3尾 Cyclic Tetrapeptides Induced and Controlled by Carbo-尾3 Amino Acid

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• 作者：Anindra Sharma ; Shrikant Sharma ; Rama P. Tripathi ; Ravi Sankar Ampapathi
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：February 17, 2012
• 年：2012
• 卷：77
• 期：4
• 页码：2001-2007
• 全文大小：339K
• 年卷期：v.77,no.4(February 17, 2012)
• ISSN：1520-6904

文摘

Designing cyclic tetrapeptides (CTPs), which fold into desired structures, is often a challenging task. While it is difficult to synthesize them, they are also prone to adopt multiple conformations. In this paper we report the synthesis and conformational studies of CTP mimics, having nonconstrained 伪₃尾 motif, that exhibit stable 尾- and 纬-turn structures. We also demonstrate the transformation of 尾-turn to 纬-turn structure in similar CTPs by inverting the chirality of 尾³ carbon in C-linked-carbo-尾³-amino acid (Caa) from R to S.