Anti-inflammatory and Antifibrotic Effects of Naringenin in Diabetic Mice
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- 作者：Shih-Jei Tsai ; Chin-Shiu Huang ; Mei-Chin Mong ; Wing-Yiu Kam ; Hui-Ying Huang ; Mei-Chin Yin
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：January 11, 2012
- 年：2012
- 卷：60
- 期：1
- 页码：514-521
- 全文大小：307K
- 年卷期：v.60,no.1(January 11, 2012)
- ISSN：1520-5118
文摘
Renal protective effects of naringenin at 0.5, 1, and 2% of the diet in diabetic mice were examined. Naringenin supplemented at 1 and 2% increased its deposit in liver and kidney of diabetic mice. Compared with the diabetic control group, naringenin treatments at 1 and 2% lowered plasma levels of glucose and blood urea nitrogen, as well as increased insulin level and creatinine clearance (P < 0.05). Naringenin treatments dose-dependently reduced renal tumor necrosis factor-伪 level and expression (P < 0.05) but only at 1 and 2% significantly decreased production and expression of interleukin (IL)-1尾, IL-6, and monocyte chemoattractant protein-1 (P < 0.05). Naringenin intake at 2% decreased renal formation and expression of type IV collagen, fibronectin, and transforming growth factor-尾1 (P < 0.05). This compound at 1 and 2% lowered protein kinase C activity and suppressed nuclear factor 魏B (NF-魏B) p65 activity, mRNA expression, and protein production in kidney. However, this agent only at 2% diminished NF-魏B p50 activity, mRNA expression, and protein production (P < 0.05). These results indicate that naringenin could attenuate diabetic nephropathy via its anti-inflammatory and antifibrotic activities.