Rh(III)-Catalyzed C鈥揌 Activation and Double Directing Group Strategy for the Regioselective Synthesis of Naphthyridinones

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• 作者：John R. Huckins ; Eric A. Bercot ; Oliver R. Thiel ; Tsang-Lin Hwang ; Matthew M. Bio
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：October 2, 2013
• 年：2013
• 卷：135
• 期：39
• 页码：14492-14495
• 全文大小：347K
• 年卷期：v.135,no.39(October 2, 2013)
• ISSN：1520-5126

文摘

A general Rh(III)-catalyzed synthesis of naphthyridinone derivatives is described. It relies on a double-activation and directing approach leveraging nicotinamide N-oxides as substrates. In general, high yields and selectivities can be achieved using low catalyst loadings and mild conditions (room temperature) in the couplings with alkynes, while alkenes require slightly more elevated temperatures.