Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Fungus Aspergillus amoenus: Biogenetic Implications

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• 作者：Hikaru Kato ; Takashi Nakahara ; Kayo Sugimoto ; Kanae Matsuo ; Ippei Kagiyama ; Jens C. Frisvad ; David H. Sherman ; Robert M. Williams ; Sachiko Tsukamoto
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：700-703
• 全文大小：402K
• ISSN：1523-7052

文摘

Notoamide S has been hypothesized to be a key biosynthetic intermediate for characteristic metabolites stephacidin A, notoamide B, and versicolamide B in Aspergillus sp. but has not yet been isolated. The isolation of notoamide S and an enantiomeric mixture of 6-epi-stephacidin A enriched with the (鈭?-isomer from Aspergillus amoenus is reported. The presence of (+)-versicolamide B suggests that the fungus possesses only the oxidase, which converts (+)-6-epi-stephacidin A into (+)-Versicolamide B, but not for (鈭?-6-epi-Stephacidin A.