An Expeditious Route toward Pyrazine-Containing Nucleoside Analogues

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• 作者：Sachin G. Modha ; Jalpa C. Trivedi ; Vaibhav P. Mehta ; Denis S. Ermolat鈥檈v ; Erik V. Van der Eycken
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：February 4, 2011
• 年：2011
• 卷：76
• 期：3
• 页码：846-856
• 全文大小：1136K
• 年卷期：v.76,no.3(February 4, 2011)
• ISSN：1520-6904

文摘

An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.