Monanchocidin: A New Apoptosis-Inducing Polycyclic Guanidine Alkaloid from the Marine Sponge Monanchora pulchra
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- 作者：Alla G. Guzii ; Tatyana N. Makarieva ; Vladimir A. Denisenko ; Pavel S. Dmitrenok ; Alexandra S. Kuzmich ; Sergey A. Dyshlovoy ; Vladimir B. Krasokhin ; Valentin A. Stonik
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：October 1, 2010
- 年：2010
- 卷：12
- 期：19
- 页码：4292-4295
- 全文大小：173K
- 年卷期：v.12,no.19(October 1, 2010)
- ISSN：1523-7052
文摘
Monanchocidin (1), a guanidine alkaloid with an unprecedented skeleton system derived from a polyketide precursor, (ω-3)-hydroxy fatty acid, and containing a 2-aminoethyl- and 3-aminopropyl-substituted morpholine hemiketal ring, has been isolated from the sponge Monanhora pulchra. The structure of 1 was assigned on the basis of detailed analysis of 1D and 2D NMR spectra, mass spectrometry, and results of chemical transformations. Compound 1 shows pro-apoptotic and cytoxic activities.