Manganous Phosphate Acts as a Superoxide Dismutase

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• 作者：Kevin Barnese ; Edith B. Gralla ; Diane E. Cabelli ; Joan Selverstone Valentine
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：April 9, 2008
• 年：2008
• 卷：130
• 期：14
• 页码：4604 - 4606
• 全文大小：91K
• 年卷期：v.130,no.14(April 9, 2008)
• ISSN：1520-5126

文摘

A substantial body of evidence indicates that high intracellular concentrations of inorganic manganous ions render some cells resistant to ionizing radiation and provide substantial antioxidant protection to aerobic cells lacking superoxide dismutase (SOD) enzymes. We found that manganous phosphate is unique among those manganous salts studied in its ability to remove superoxide rapidly and catalytically from aqueous solution via a disproportionation mechanism that is entirely different from those of the SOD enzymes.